Which of the following is a common side effect associated with high doses of herbal supplements?

High doses of herbal supplements are often associated with gastrointestinal disturbances, making this choice the most accurate among the options presented. Many herbal supplements can stimulate the digestive system, leading to symptoms such as nausea, diarrhea, and abdominal discomfort. These disturbances can arise from the body's response to concentrated compounds found in herbs, which may irritate the gastrointestinal lining or disrupt normal digestive processes.

Additionally, the specific active ingredients in various herbal supplements can vary widely, and some may have a more pronounced effect on the digestive system than others. This is particularly relevant when supplements are taken in larger quantities, as the concentration of these compounds increases the likelihood of adverse reactions.

Understanding this connection highlights the importance of using herbal supplements responsibly and being aware of potential side effects, especially when considering dosage.